Protein Details: Aquaporin-2

Protein ID

ICDB_Pro_0627

Protein Name

Aquaporin-2

Gene Name

Aqp2; cph

Organism

Mus musculus (Mouse)

Length

271 amino acids

AlphaFoldDB

AF-P56402-F1-model_v4.pdb

Function

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water;thereby permitting water to move in the direction of an osmotic gradient . Plays an essential role in renal water homeostasis .

Sequence

MWELRSIAFSRAVLAEFLATLLFVFFGLGSALQWASSPPSVLQIAVAFGLGIGTLVQALGHVSGAHINPAVTVACLVGCHVSFLRAAFYVAAQLLGAVAGAAILHEITPVEIRGDLAVNALHNNATAGQAVTVELFLTMQLVLCIFASTDERRSDNLGSPALSIGFSVTLGHLLGIYFTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAVIGSLLYNYLLFPSTKSLQERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGSKA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

diarrhea

Location

Detected in principal cells in the collecting duct in kidney medulla and cortex (at protein level) (PubMed:10191086;PubMed:16641094;PubMed:16735444;PubMed:31605441). Expressed in a radial pattern from the cortex through the outer medulla into the inner medulla (PubMed:12426236). Higher levels in the inner medulla (PubMed:12426236). Higher levels in the inner medulla (PubMed:12426236). Higher levels in the inner medulla (PubMed:12426236).

DOI ID

10.1006/geno.1999.5759; 10.1152/ajprenal.0224.2001; 10.1101/gr.2596504; 10.1242/jcs.02971; 10.1073/pnas.0602087103; 10.1016/j.cell.2010.12.001; 10.1111/febs.15088

RefSeq

NP_033829.3